How to use natural progesterone cream

What is progesterone and USP natural progesterone?

Progesterone is a steroid hormone produced from cholesterol in the ovaries by the corpus luteum (the tissue that is left behind after ovulation). It is also produced in the adrenal gland in smaller quantities. It is converted in the body to produce other steroid hormones like estrogen, testosterone, cortisol and androstenedione. The main aim of progesterone in women is to sustain any pregnancy that may arise from fertilization of the egg released from the ovary during ovulation.

Progesterone is manufactured from Diosgenin, a substance found in Mexican Wild Yam and also from soybeans. It is converted to bioidentical progesterone in the laboratory.
USP stands for United States Pharmaceutical grade. This means that the progesterone is extracted under the strictest conditions to ensure that it the same as the progesterone that is produced in your body by the corpus luteum and that it is of the highest quality. You may see wild yam creams or those with mexican yam extract. These are a total waste of money! They contain only diosgenin which is cheaper than bioidentical progesterone. It cannot be converted to progesterone in the body. It will not improve your symptoms.

Use natural, bioidentical progesterone cream for progesterone deficiency and estrogen dominance symptoms and PMS

natural progesterone cream, PMS, estrogen dominanceMore and more women are using bioidentical hormones to relieve menopause symptoms. Natural progesterone cream can be used to manage a number of problems that are related to hormonal imbalance.

  • General guidelines for using natural progesterone
  • PMS
  • Hysterectomy
  • Premenopausal women
  • Fibrocystic breast disease
  • Endometriosis
  • Menstrual migraine headaches

General guidelines for using bioidentical progesterone cream

  • Spread the cream thinly over a large area of skin for maximum absorption.
  • Make sure skin is clean and clear of cosmetics. Do not apply other skin creams in the same area on the same day.
  • Apply to areas like the breasts, chest, inner thighs, buttocks and neck where skin is thinnest.
  • Don’t be concerned about getting the exact amount of cream correct. The progesterone is absorbed continuously from the skin.
  • If you are using a large dose, split it. Use 1/3 of the dose in the morning and 2/3 at bedtime. The higher dose is especially useful if you have trouble sleeping at night.
  • Buy good quality bioidentical progesterone cream from a reputable vendor. You have to be careful for the following reason
    1. the cream will not be effective if it is not suspended in the right medium
    2. creams containing mineral oil will not be absorbed properly
    3. the progesterone in some creams is not properly stabilized so it breaks down fast, making the cream useless
    4. some products containing wild yam extract don’t contain any progesterone
    5. some creams contain other chemicals that may cause allergic reactions and rashes


  1. Should natural progesterone cream be stopped before an operation? If yes, for how long should it be stopped?

  2. Does natural estrogen cream cause high blood pressure? I’ve been pulled off of synthetic bcp due to that problem and am seeking alternatives…

  3. I had a question about progesterone cream. I hit menopause and stopped having periods over a year ago. I was using the cream to help manage symptoms. When i stopped, exactly one month later i got a period. And again this month i got a period, just as severe as they have alwasy been. Could there be any correlation?

  4. Hi Vinola. Sorry for taking so long to reply. I’m sorry to hear about your distress. What was the reason for the hysterectomy if I may ask a personal question?
    What brand of progesterone cream are you using? You need to make sure it’s a good quality product and you may need a double strength cream like Oasis Serene Plus.
    Another thing you need to take into consideration is your general health.

    • Do you have any thyroid hormone imbalances? This is one of the most common causes of hair loss. You need to see your doctor to check this out.
    • What is your diet like? Are you getting enough protein and iron which are essential for healthy hair growth
    • Do you get any exercise?
    • Are you taking supplements?
    • Are you under a lot of physical or emotional stress?
    • Are you taking any medication that may be causing the problem?
    • There are a lot of things you need to consider. But first see your doctor for a check up. If all is well then consider using a combined natural estrogen + natural progesterone cream if you don’t have a problem with estrogen.
      You should try and use your cream for at least 3-4 months before you consider changing.
      Soy proteins are also another option that some women have found useful.

  5. Pleasr help me . I have had a hysterectomy about 4 years ago. I suffered terrible hair loss. The bioidentical hormones did help but only for a while..I seem to need very high doses of progesterone to stop my hair loss, I start with a certain dose and then I seem to need more and more, I was told prolonged use of progesterone can cause hair loss. How much should I actually be taking a day and how?
    please help

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